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Select item 104145981.

A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases

Wei Liu, Wenxuan Deng, Ming Chen, Zihan Dong, Biqing Zhu, Zhaolong Yu, Daiwei Tang, Maor Sauler, Chen Lin, Louise V. Wain, Michael H. Cho, Naftali Kaminski, Hongyu Zhao

PLoS Genet. 2023 Jul; 19(7): e1010825. Published online 2023 Jul 31. doi: 10.1371/journal.pgen.1010825

PMCID:: PMC10414598

Article PDF–2.9M

Select item 98818842.

The genetic architecture of the human skeletal form

Eucharist Kun, Emily M. Javan, Olivia Smith, Faris Gulamali, Javier de la Fuente, Brianna I. Flynn, Kushal Vajrala, Zoe Trutner, Prakash Jayakumar, Elliot M. Tucker-Drob, Mashaal Sohail, Tarjinder Singh, Vagheesh M. Narasimhan

Version 1. bioRxiv. Preprint. 2023 Jan 3. doi: 10.1101/2023.01.03.521284

Published in:: Science. 2023 Jul 21; 381(6655): eadf8009.

PMCID:: PMC9881884

Article PDF–19M

Select item 99437193.

Challenges of accurately estimating sex-biased admixture from X chromosomal and autosomal ancestry proportions

Aaron Pfennig, Joseph Lachance

Am J Hum Genet. 2023 Feb 2; 110(2): 359–367. Published online 2023 Feb 2. doi: 10.1016/j.ajhg.2022.12.012

PMCID:: PMC9943719

Article PDF–889K

Select item 103885324.

The effects of high plasma levels of Aβ_1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease

Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu

Immun Ageing. 2023; 20: 39. Published online 2023 Jul 31. doi: 10.1186/s12979-023-00366-4

PMCID:: PMC10388532

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Select item 101075105.

Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue

Megha Murthy, Gemma Shireby, Yasuo Miki, Emmanuelle Viré, Tammaryn Lashley, Thomas T. Warner, Jonathan Mill, Conceição Bettencourt

Neuropathol Appl Neurobiol. 2023 Feb; 49(1): e12872. Published online 2023 Jan 11. doi: 10.1111/nan.12872

PMCID:: PMC10107510

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Select item 107275066.

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna M Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal A Goff, Pankaj Jay Pasricha

eLife. 2023; 12: RP88051. Published online 2023 Dec 18. doi: 10.7554/eLife.88051

PMCID:: PMC10727506

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Select item 74519797.

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

Ellis Patrick, Mariko Taga, Ayla Ergun, Bernard Ng, William Casazza, Maria Cimpean, Christina Yung, Julie A. Schneider, David A. Bennett, Chris Gaiteri, Philip L. De Jager, Elizabeth M. Bradshaw, Sara Mostafavi

PLoS Comput Biol. 2020 Aug; 16(8): e1008120. Published online 2020 Aug 17. doi: 10.1371/journal.pcbi.1008120

PMCID:: PMC7451979

Article PDF–1.6M

Select item 64833548.

Insights from deconvolution of cell subtype proportions enhance the interpretation of functional genomic data

Yu Kong, Deepa Rastogi, Cathal Seoighe, John M. Greally, Masako Suzuki

PLoS One. 2019; 14(4): e0215987. Published online 2019 Apr 25. doi: 10.1371/journal.pone.0215987

PMCID:: PMC6483354

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Select item 99765439.

Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions

Abner T. Apsley, Laura Etzel, Waylon J. Hastings, Christine C. Heim, Jennie G. Noll, Kieran J. O’Donnell, Hannah M. C. Schreier, Chad E. Shenk, Qiaofeng Ye, Idan Shalev

Clin Epigenetics. 2023; 15: 33. Published online 2023 Feb 28. doi: 10.1186/s13148-023-01437-5

PMCID:: PMC9976543

Article PDF–1.6M

Select item 1088882310.

Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex

Louise A. Huuki-Myers, Kelsey D. Montgomery, Sang Ho Kwon, Sophia Cinquemani, Nicholas J. Eagles, Daianna Gonzalez-Padilla, Sean K. Maden, Joel E. Kleinman, Thomas M. Hyde, Stephanie C. Hicks, Kristen R. Maynard, Leonardo Collado-Torres

Version 2. bioRxiv. Preprint. 2024 Feb 12 [revised 2024 Apr 7]. doi: 10.1101/2024.02.09.579665

PMCID:: PMC10888823

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Select item 1039907211.

BEDwARS: a robust Bayesian approach to bulk gene expression deconvolution with noisy reference signatures

Saba Ghaffari, Kelly J. Bouchonville, Ehsan Saleh, Remington E. Schmidt, Steven M. Offer, Saurabh Sinha

Genome Biol. 2023; 24: 178. Published online 2023 Aug 3. doi: 10.1186/s13059-023-03007-7

PMCID:: PMC10399072

Article PDF–1.9M

Select item 960877712.

Altered transcription factor targeting is associated with differential peripheral blood mononuclear cell proportions in sarcoidosis

Christian Ascoli, Cody A. Schott, Yue Huang, Benjamin A. Turturice, Wangfei Wang, Naomi Ecanow, Nadera J. Sweiss, David L. Perkins, Patricia W. Finn

Front Immunol. 2022; 13: 848759. Published online 2022 Oct 13. doi: 10.3389/fimmu.2022.848759

PMCID:: PMC9608777

Article PDF–9.4M

Select item 653025513.

Resistance proportions for eight priority antibiotic-bacterium combinations in OECD, EU/EEA and G20 countries 2000 to 2030: a modelling study

Tiago Cravo Oliveira Hashiguchi, Driss Ait Ouakrim, Michael Padget, Alessandro Cassini, Michele Cecchini

Euro Surveill. 2019 May 16; 24(20): 1800445. doi: 10.2807/1560-7917.ES.2019.24.20.1800445

PMCID:: PMC6530255

Article PDF–558K

Select item 484953314.

Elevated CD1c⁺ Myeloid Dendritic Cell Proportions Associate With Clinical Activity and Predict Disease Reactivation in Noninfectious Uveitis

Ping Chen, Cristhian A. Urzua, Jared E. Knickelbein, Jane S. Kim, Zhiyu Li, Susan Hannes, David Kuo, Benjamin Chaigne-Delalande, Karen Armbrust, William Tucker, Baoying Liu, Elvira Agrón, H. Nida Sen, Robert B. Nussenblatt

Invest Ophthalmol Vis Sci. 2016 Apr; 57(4): 1765–1772. Published online 2016 Apr 12. doi: 10.1167/iovs.15-18357

PMCID:: PMC4849533

Article PDF–899K

Select item 650145615.

Calculating incidence rates and prevalence proportions: not as simple as it seems

Inge Spronk, Joke C. Korevaar, René Poos, Rodrigo Davids, Henk Hilderink, François G. Schellevis, Robert A. Verheij, Mark M. J. Nielen

BMC Public Health. 2019; 19: 512. Published online 2019 May 6. doi: 10.1186/s12889-019-6820-3

PMCID:: PMC6501456

Article PDF–586K

Select item 1078949916.

Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease

Anael Cain, Mariko Taga, Cristin McCabe, Gilad S. Green, Idan Hekselman, Charles C. White, Dylan I. Lee, Pallavi Gaur, Orit Rozenblatt-Rosen, Feng Zhang, Esti Yeger-Lotem, David A. Bennett, Hyun-Sik Yang, Aviv Regev, Vilas Menon, Naomi Habib, Philip L. De Jager

Nat Neurosci. Author manuscript; available in PMC 2024 Jan 15.

Published in final edited form as: Nat Neurosci. 2023 Jul; 26(7): 1267–1280. Published online 2023 Jun 19. doi: 10.1038/s41593-023-01356-x